hdpp4 mice Search Results


hdpp4 mice  (inGenious Targeting Laboratory)
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inGenious Targeting Laboratory hdpp4 mice
Detection of <t>hDPP4</t> expression in hDPP4 mice using immunohistochemistry in ( a ) nasal mucosa; ( b ) trachea; and ( c ) type I and II pneumocytes, bronchiolar and endothelial cells in lung tissue. d Comparison of hDPP4 expression in lung and kidney tissue obtained from wildtype and hDPP4 mice using flow cytometry. N = 3, bars represent median. e Survival curves of mice after inoculation with 5 × 10 5 TCID 50 MERS-CoV. N = 4 (Wildtype) or 5 (hDPP4). ** = p < 0.01. f Relative weight loss in mice after MERS-CoV inoculation. The lines represent median±range. Mice were euthanized upon reaching >20% of body weight loss (dotted line). g Viral load (gRNA) in oropharyngeal swabs obtained from mice after inoculation with 5 × 10 5 TCID 50 MERS-CoV. h Infectious MERS-CoV titers in lung, brain, and kidney tissue of hDPP4 mice. Dotted line detection limit.
Hdpp4 Mice, supplied by inGenious Targeting Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/hdpp4+mice/pmc11721671-130-0-5?v=inGenious+Targeting+Laboratory
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hdpp4 mice - by Bioz Stars, 2026-08
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Detection of hDPP4 expression in hDPP4 mice using immunohistochemistry in ( a ) nasal mucosa; ( b ) trachea; and ( c ) type I and II pneumocytes, bronchiolar and endothelial cells in lung tissue. d Comparison of hDPP4 expression in lung and kidney tissue obtained from wildtype and hDPP4 mice using flow cytometry. N = 3, bars represent median. e Survival curves of mice after inoculation with 5 × 10 5 TCID 50 MERS-CoV. N = 4 (Wildtype) or 5 (hDPP4). ** = p < 0.01. f Relative weight loss in mice after MERS-CoV inoculation. The lines represent median±range. Mice were euthanized upon reaching >20% of body weight loss (dotted line). g Viral load (gRNA) in oropharyngeal swabs obtained from mice after inoculation with 5 × 10 5 TCID 50 MERS-CoV. h Infectious MERS-CoV titers in lung, brain, and kidney tissue of hDPP4 mice. Dotted line detection limit.

Journal: npj Viruses

Article Title: Transmission dynamics of MERS-CoV in a transgenic human DPP4 mouse model

doi: 10.1038/s44298-024-00048-y

Figure Lengend Snippet: Detection of hDPP4 expression in hDPP4 mice using immunohistochemistry in ( a ) nasal mucosa; ( b ) trachea; and ( c ) type I and II pneumocytes, bronchiolar and endothelial cells in lung tissue. d Comparison of hDPP4 expression in lung and kidney tissue obtained from wildtype and hDPP4 mice using flow cytometry. N = 3, bars represent median. e Survival curves of mice after inoculation with 5 × 10 5 TCID 50 MERS-CoV. N = 4 (Wildtype) or 5 (hDPP4). ** = p < 0.01. f Relative weight loss in mice after MERS-CoV inoculation. The lines represent median±range. Mice were euthanized upon reaching >20% of body weight loss (dotted line). g Viral load (gRNA) in oropharyngeal swabs obtained from mice after inoculation with 5 × 10 5 TCID 50 MERS-CoV. h Infectious MERS-CoV titers in lung, brain, and kidney tissue of hDPP4 mice. Dotted line detection limit.

Article Snippet: hDPP4 mice were developed by ingenious Targeting Laboratory.

Techniques: Expressing, Immunohistochemistry, Comparison, Flow Cytometry

a Survival curves of mice inoculated with 3.8 × 10 2 TCID 50 MERS-CoV via aerosols. N = 6. b Viral load (gRNA) in oropharyngeal swabs obtained from mice inoculated with 3.8 × 10 2 TCID 50 MERS-CoV via aerosols. Bars represent median. b Viral load (gRNA) and c (infectious virus) in lung and brain tissue of hDPP4 mice inoculated with 3.8 × 10 2 TCID 50 MERS-CoV via aerosols.

Journal: npj Viruses

Article Title: Transmission dynamics of MERS-CoV in a transgenic human DPP4 mouse model

doi: 10.1038/s44298-024-00048-y

Figure Lengend Snippet: a Survival curves of mice inoculated with 3.8 × 10 2 TCID 50 MERS-CoV via aerosols. N = 6. b Viral load (gRNA) in oropharyngeal swabs obtained from mice inoculated with 3.8 × 10 2 TCID 50 MERS-CoV via aerosols. Bars represent median. b Viral load (gRNA) and c (infectious virus) in lung and brain tissue of hDPP4 mice inoculated with 3.8 × 10 2 TCID 50 MERS-CoV via aerosols.

Article Snippet: hDPP4 mice were developed by ingenious Targeting Laboratory.

Techniques: Virus

hDPP4 mice were exposed to 5 × 10 4 TCID 50 MERS-CoV ( N = 18) or 5 × 10 6 TCID 50 MERS-CoV ( N = 20). a Survival curves of hDPP4 mice exposed to fomites containing MERS-CoV. Viral gRNA ( b ) or sgRNA ( c ) in lung and brain tissue of hDPP4 mice that reached endpoint criteria. d Infectious MERS-CoV detected in lung and brain tissue of hDPP4 mice that reached endpoint criteria. e Serology titers in sera of survivors obtained 28 dpe. ELISA assays were performed using MERS-CoV S1 protein. Dotted line = limit of detection. ** = p < 0.01.

Journal: npj Viruses

Article Title: Transmission dynamics of MERS-CoV in a transgenic human DPP4 mouse model

doi: 10.1038/s44298-024-00048-y

Figure Lengend Snippet: hDPP4 mice were exposed to 5 × 10 4 TCID 50 MERS-CoV ( N = 18) or 5 × 10 6 TCID 50 MERS-CoV ( N = 20). a Survival curves of hDPP4 mice exposed to fomites containing MERS-CoV. Viral gRNA ( b ) or sgRNA ( c ) in lung and brain tissue of hDPP4 mice that reached endpoint criteria. d Infectious MERS-CoV detected in lung and brain tissue of hDPP4 mice that reached endpoint criteria. e Serology titers in sera of survivors obtained 28 dpe. ELISA assays were performed using MERS-CoV S1 protein. Dotted line = limit of detection. ** = p < 0.01.

Article Snippet: hDPP4 mice were developed by ingenious Targeting Laboratory.

Techniques: Enzyme-linked Immunosorbent Assay

hDPP4 mice were inoculated intranasally with 10 4 TCID 50 MERS-CoV ( N = 20) or 10 5 TCID 50 MERS-CoV ( N = 38). a Survival curves of mice directly exposed to donor mice infected with MERS-CoV. Viral gRNA ( b ) or sgRNA ( c ) in lung and brain tissue of hDPP4 mice that reached endpoint criteria. d Infectious MERS-CoV detected in lung and brain tissue of hDPP4 mice that reached endpoint criteria. e Serology titers in sera of survivors obtained 28 dpe. ELISA assays were performed using MERS-CoV S1 protein. Dotted line = limit of detection.

Journal: npj Viruses

Article Title: Transmission dynamics of MERS-CoV in a transgenic human DPP4 mouse model

doi: 10.1038/s44298-024-00048-y

Figure Lengend Snippet: hDPP4 mice were inoculated intranasally with 10 4 TCID 50 MERS-CoV ( N = 20) or 10 5 TCID 50 MERS-CoV ( N = 38). a Survival curves of mice directly exposed to donor mice infected with MERS-CoV. Viral gRNA ( b ) or sgRNA ( c ) in lung and brain tissue of hDPP4 mice that reached endpoint criteria. d Infectious MERS-CoV detected in lung and brain tissue of hDPP4 mice that reached endpoint criteria. e Serology titers in sera of survivors obtained 28 dpe. ELISA assays were performed using MERS-CoV S1 protein. Dotted line = limit of detection.

Article Snippet: hDPP4 mice were developed by ingenious Targeting Laboratory.

Techniques: Infection, Enzyme-linked Immunosorbent Assay

hDPP4 mice were inoculated intranasally with 10 4 TCID 50 MERS-CoV ( N = 5) or 10 5 TCID 50 MERS-CoV ( N = 54). a Survival curves of mice exposed to donor mice infected with MERS-CoV. Viral gRNA ( b ) or sgRNA ( c ) in lung and brain tissue of hDPP4 mice that reached endpoint criteria. d Infectious MERS-CoV detected in lung and brain tissue of hDPP4 mice that reached endpoint criteria. e Serology titers in sera of survivors obtained 28 dpe. ELISA assays were performed using MERS-CoV S1 protein. Dotted line = limit of detection.

Journal: npj Viruses

Article Title: Transmission dynamics of MERS-CoV in a transgenic human DPP4 mouse model

doi: 10.1038/s44298-024-00048-y

Figure Lengend Snippet: hDPP4 mice were inoculated intranasally with 10 4 TCID 50 MERS-CoV ( N = 5) or 10 5 TCID 50 MERS-CoV ( N = 54). a Survival curves of mice exposed to donor mice infected with MERS-CoV. Viral gRNA ( b ) or sgRNA ( c ) in lung and brain tissue of hDPP4 mice that reached endpoint criteria. d Infectious MERS-CoV detected in lung and brain tissue of hDPP4 mice that reached endpoint criteria. e Serology titers in sera of survivors obtained 28 dpe. ELISA assays were performed using MERS-CoV S1 protein. Dotted line = limit of detection.

Article Snippet: hDPP4 mice were developed by ingenious Targeting Laboratory.

Techniques: Infection, Enzyme-linked Immunosorbent Assay